Institut National de la Santé et de la Recherche Médicale UMRs 952, Centre National de Recherche Scientifique UMR 7224, Université Pierre et Marie Curie, 75252 Paris Cedex 05, France.
J Neurosci. 2013 Mar 27;33(13):5718-27. doi: 10.1523/JNEUROSCI.5248-12.2013.
Previous studies in monkeys disclosed a specific arrangement of corticostriatal projections. Prefrontal and premotor areas form dense projection fields surrounded by diffuse terminal areas extending outside the densely innervated region and overlapping with projections from other areas. In this study, the mode of prefrontostriatal innervation was analyzed in rats using a 3D approach. Following injections of tracers in defined cortical areas, 3D maps from individual cases were elaborated and combined into a global 3D map allowing us to define putative overlaps between projection territories. In addition to providing a detailed 3D mapping of the topographic representation of prefrontal cortical areas in the rat striatum, the results stress important similarities between the rodent and primate prefrontostriatal projections. They share the dual pattern of focal and diffuse corticostriatal projections. Moreover, besides segregated projections consistent with parallel processing, the interweaving of projection territories establishes specific patterns of overlaps spatially organized along the dorsoventral, mediolateral, and anteroposterior striatal axis. In particular, the extensive striatal projection fields from the prelimbic and anterior cingulate areas, which partly overlap the terminal fields from medial, orbital, and lateral prefrontal cortical areas, provide putative domains of convergence for integration between reward, cognitive, and motor processes.
先前在猴子身上进行的研究揭示了皮质纹状体投射的特定排列方式。前额叶和前运动区形成密集的投射区，被延伸到密集神经支配区域之外的弥散终末区所包围，并与来自其他区域的投射重叠。在这项研究中，我们使用 3D 方法分析了大鼠的前额皮质纹状体投射模式。在确定的皮质区域注射示踪剂后，从单个病例中详细阐述 3D 图谱，并将其组合成一个全局 3D 图谱，使我们能够定义投射区域之间的潜在重叠。除了提供大鼠纹状体中前额皮质区域的地形代表的详细 3D 映射外，结果还强调了啮齿动物和灵长类动物前额皮质纹状体投射之间的重要相似性。它们共享焦点和弥散皮质纹状体投射的双重模式。此外，除了与平行处理一致的分离投射外，投射区域的交织还沿着背腹、内外侧和前后纹状体轴在空间上建立了特定的重叠模式。特别是来自前额叶皮层的背侧和前扣带区域的广泛纹状体投射区，部分重叠来自内侧、眶额和外侧前额皮质区域的终末区，为奖励、认知和运动过程之间的整合提供了潜在的汇聚域。
