Schneider Marguerite Reid, Klein Christina C, Weber Wade, Bitter Samantha M, Elliott Kimberly B, Strakowski Stephen M, Adler Caleb M, DelBello Melissa P
Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Graduate Program in Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Division of Bipolar Disorders Research, Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Psychiatry Res. 2014 Sep 30;223(3):268-70. doi: 10.1016/j.pscychresns.2014.04.011. Epub 2014 Apr 29.
This preliminary study investigated the neurofunctional effects of carbamazepine-extended release (XR) treatment in 11 manic youth with bipolar disorder during performance of a sustained attention task, the Continuous Performance Task - Identical Pairs version (CPT-IP), during functional magnetic resonance imaging (fMRI). All patients underwent baseline fMRI, and 10 patients were scanned again at endpoint. Nine demographically matched healthy youth, who were scanned once, served as controls. Carbamazepine-XR treatment was associated with normalization of activation in right Brodmann area 10 (BA). These results suggest that carbamazepine-XR treatment may correct prefrontal dysfunction in adolescent mania.
这项初步研究在功能磁共振成像（fMRI）期间，对11名患有双相情感障碍的躁狂青年进行持续注意力任务（连续性能任务 - 相同配对版本，CPT - IP）时，调查了卡马西平缓释（XR）治疗的神经功能影响。所有患者均接受了基线fMRI检查，10名患者在终点时再次进行扫描。9名在人口统计学上匹配的健康青年进行了一次扫描，作为对照。卡马西平 - XR治疗与右侧布罗德曼区10（BA）激活的正常化有关。这些结果表明，卡马西平 - XR治疗可能纠正青少年躁狂症中的前额叶功能障碍。
