醋酸亮丙瑞林长效注射剂用于治疗性早熟。
Depot leuprolide acetate for treatment of precocious puberty.
作者信息
Parker K L, Lee P A
机构信息
Department of Pediatrics, University of Pittsburgh School of Medicine, Pennsylvania.
出版信息
J Clin Endocrinol Metab. 1989 Sep;69(3):689-91. doi: 10.1210/jcem-69-3-689.
PMID:2503536
Abstract
Leuprolide acetate (D-Leu 6 des-Gly-NH2(10), Pro-ethylamide9) for depot suspension has been shown to be effective in suppressing gonadotropins in 6 patients. Serum LH and FSH response to exogenous LHRH was obliterated after 4 weeks and weekly urinary gonadotropin levels during depot therapy were suppressed. This form of this drug should be effective in the treatment of precocious puberty.
摘要
已证明，用于长效混悬液的醋酸亮丙瑞林（D-亮氨酸6 去甘氨酰胺（10），脯氨酸乙酯9）对6例患者的促性腺激素有抑制作用。4周后，血清促黄体生成素（LH）和促卵泡生成素（FSH）对外源性促性腺激素释放激素（LHRH）的反应消失，长效治疗期间每周的尿促性腺激素水平受到抑制。这种药物剂型应可有效治疗性早熟。
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