血液病恶性肿瘤侵袭性真菌感染治疗推荐：证据的批判性回顾和土耳其专家意见（TEO-1）。
Recommendations for the Treatment of Invasive Fungal Infections in Hematological Malignancies: A Critical Review of Evidence and Turkish Expert Opinion (TEO-1).
机构信息
Ankara University Faculty of Medicine Cebeci Campus, Department of Hematology, Ankara, Turkey.
İstanbul University Cerrahpaşa Faculty of Medicine, Department of Hematology, İstanbul, Turkey.
出版信息
Turk J Haematol. 2014 Jun;31(2):111-20. doi: 10.4274/tjh.2014.0103. Epub 2014 Jun 10.
Abstract
The introduction of novel antifungal agents for the treatment of invasive fungal disease in hematological malignancies and also changing treatment strategies have had a great impact in managing affected patients. The medical literature includes some important clinical studies that are being used as evidence for guidelines. The problem with these studies and the guidelines is that they are not very easy to interpret, they include controversial issues, and they are not easy to apply to every patient or country. This paper was designed to critically show the main problems associated with these approaches and provide important information that will help Turkish doctors to adopt them in daily clinical practice.
摘要
新型抗真菌药物的引入治疗血液系统恶性肿瘤的侵袭性真菌病，以及治疗策略的改变，对治疗受影响的患者产生了重大影响。医学文献中包含一些重要的临床研究，这些研究被用作指南的证据。这些研究和指南存在一些问题，比如不太容易解读，存在争议性问题，而且不容易适用于每个患者或国家。本文旨在批判性地展示这些方法所涉及的主要问题，并提供重要信息，帮助土耳其医生在日常临床实践中采用这些方法。
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本文引用的文献
1
Empirical versus pre-emptive antifungal therapy for persistent febrile neutropenia.经验性抗真菌治疗与抢先抗真菌治疗用于持续性发热性中性粒细胞减少症的比较
Haematologica. 2012 Jan;97(1):e1. doi: 10.3324/haematol.2011.056077.
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Universal antifungal therapy is not needed in persistent febrile neutropenia: a tailored diagnostic and therapeutic approach.持久发热性中性粒细胞减少症中无需使用通用抗真菌治疗：一种针对性的诊断和治疗方法。
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The use and efficacy of empirical versus pre-emptive therapy in the management of fungal infections: the HEMA e-Chart Project.经验性治疗与抢先性治疗在真菌感染管理中的应用和疗效：HEMA 电子图表项目。
Haematologica. 2011 Sep;96(9):1366-70. doi: 10.3324/haematol.2011.042598. Epub 2011 May 12.
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What does preemptive antifungal treatment really mean?抢先抗真菌治疗究竟意味着什么？
Clin Infect Dis. 2010 Apr 15;50(8):1201-2; author reply 1202. doi: 10.1086/651470.
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Clinically driven diagnostic antifungal approach in neutropenic patients: a prospective feasibility study.临床驱动的中性粒细胞减少症患者诊断性抗真菌方法：一项前瞻性可行性研究。
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Empirical versus preemptive antifungal therapy for fever during neutropenia.中性粒细胞减少症发热时经验性抗真菌治疗与抢先抗真菌治疗的对比
Clin Infect Dis. 2009 Oct 1;49(7):1138-9; author reply 1139-40. doi: 10.1086/605601.
7
Timely intervention for invasive fungal disease: should the road now lead to the laboratory instead of the pharmacy?侵袭性真菌病的及时干预：现在这条路应该通向实验室而非药房吗？
Clin Infect Dis. 2009 Apr 15;48(8):1052-4. doi: 10.1086/597396.
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Empirical versus preemptive antifungal therapy for high-risk, febrile, neutropenic patients: a randomized, controlled trial.经验性抗真菌治疗与抢先抗真菌治疗用于高危、发热、中性粒细胞减少患者的随机对照试验
Clin Infect Dis. 2009 Apr 15;48(8):1042-51. doi: 10.1086/597395.
9
Recent advances in antifungal chemotherapy.抗真菌化疗的最新进展。
Int J Antimicrob Agents. 2007 Aug;30(2):108-17. doi: 10.1016/j.ijantimicag.2007.03.009. Epub 2007 May 23.
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Between over- and undertreatment of invasive fungal disease.侵袭性真菌病治疗过度与治疗不足之间的情况。
Clin Infect Dis. 2005 Nov 1;41(9):1251-3. doi: 10.1086/496933. Epub 2005 Sep 29.
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