Valković Toni, Damić Marija Stanić
Department of Hematology, University Hospital Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.
Faculty of Medicine Rijeka, University of Rijeka, Braće Branchetta 20, 51000 Rijeka, Croatia.
J Clin Med. 2022 Jul 30;11(15):4457. doi: 10.3390/jcm11154457.
Iron is an essential trace metal necessary for the reproduction and survival of fungal pathogens. The latter have developed various mechanisms to acquire iron from their mammalian hosts, with whom they participate in a continuous struggle for dominance over iron. Invasive fungal infections are an important problem in the treatment of patients with hematological malignancies, and they are associated with significant morbidity and mortality. The diagnosis of invasive clinical infections in these patients is complex, and the treatment, which must occur as early as possible, is difficult. There are several studies that have shown a possible link between iron overload and an increased susceptibility to infections. This link is also relevant for patients with hematological malignancies and for those treated with allogeneic hematopoietic stem cell transplantation. The role of iron and its metabolism in the virulence and pathogenesis of various invasive fungal infections is intriguing, and so far, there is some evidence linking invasive fungal infections to iron or iron overload. Clarifying the possible association of iron and iron overload with susceptibility to invasive fungal infections could be important for a better prevention and treatment of these infections in patients with hematological malignancies.
铁是真菌病原体繁殖和生存所必需的微量金属。后者已发展出多种机制从其哺乳动物宿主获取铁，它们与宿主围绕铁的主导权展开持续争夺。侵袭性真菌感染是血液系统恶性肿瘤患者治疗中的一个重要问题，且与显著的发病率和死亡率相关。这些患者侵袭性临床感染的诊断复杂，而必须尽早进行的治疗也很困难。有多项研究表明铁过载与感染易感性增加之间可能存在关联。这种关联对于血液系统恶性肿瘤患者以及接受异基因造血干细胞移植治疗的患者也具有相关性。铁及其代谢在各种侵袭性真菌感染的毒力和发病机制中的作用引人关注，到目前为止，有一些证据将侵袭性真菌感染与铁或铁过载联系起来。阐明铁和铁过载与侵袭性真菌感染易感性之间可能的关联，对于更好地预防和治疗血液系统恶性肿瘤患者的这些感染可能具有重要意义。
