肿瘤抑制因子TSLC1抑制Eca109细胞裸鼠移植瘤的生长、增殖、侵袭及血管生成。
Tumor suppressor TSLC1 inhibits growth, proliferation, invasiveness and angiogenesis in nude mice xenografted tumor of Eca109 cells.
作者信息
Liang Qi-Lian, Chen Guo-Qiang, Liu Qiu-Long, Li Zhou-Yu, Zhang Xiang-Ning, Zhou Yuan, Ou Wen-Ting, Wang Bi-Rong, Hu Li-Ren
机构信息
Department of Oncology, Affiliated Hospital of Guangdong Medical College Zhanjiang, 524001, China.
Department of Radiotherapy, Cancer Center of Guangzhou Medical University Guangzhou, 510095, China.
出版信息
Int J Clin Exp Med. 2014 Jun 15;7(6):1507-15. eCollection 2014.
Tumor suppressor in lung cancer 1 (TSLC1) is a novel tumor suppressor gene whose inactivation is implicated in the occurrence, invasion, metastasis and prognosis of esophageal cancer. TSLC1 was studied by comparing the tumor formation of TSLC1 transfectant and control cells in nude mice. Compared with blank group and mock group, tumor size and infiltrating range of transfected group was less, differentiation of tumor tissue was slightly better, and differences of tumor angiogenesis was worse. There was no obvious difference between blank group and mock group. We have shown TSLC1 gene inhibited the growth proliferation, infiltration and angiogenesis of Eca109 cells.
肺癌肿瘤抑制因子1（TSLC1）是一种新型肿瘤抑制基因，其失活与食管癌的发生、侵袭、转移及预后相关。通过比较TSLC1转染细胞和对照细胞在裸鼠体内的肿瘤形成情况对TSLC1进行研究。与空白组和空载体转染组相比，转染组的肿瘤大小和浸润范围较小，肿瘤组织分化稍好，肿瘤血管生成差异较差。空白组和空载体转染组之间无明显差异。我们已表明TSLC1基因可抑制Eca109细胞的生长增殖、浸润及血管生成。
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