Dewan M Zahidunnabi, Takamatsu Naofumi, Hidaka Tomonori, Hatakeyama Kinta, Nakahata Shingo, Fujisawa Jun-ichi, Katano Harutaka, Yamamoto Naoki, Morishita Kazuhiro
Department of Molecular Virology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
J Virol. 2008 Dec;82(23):11958-63. doi: 10.1128/JVI.01149-08. Epub 2008 Oct 15.
Adult T-cell leukemia (ATL) is associated with human T-cell leukemia virus type 1 infection. The tumor suppressor lung cancer 1 (TSLC1) gene was previously identified as a novel cell surface marker for ATL, and this study demonstrated the involvement of TSLC1 expression in tumor growth and organ infiltration of ATL cells. In experiments using NOD/SCID/gamma c(null) mice, both leukemia cell lines and primary ATL cells with high TSLC1 expression caused more tumor formation and aggressive infiltration of various organs of mice. Our results suggest that TSLC1 expression in ATL cells plays an important role in the growth and organ infiltration of ATL cells.
成人T细胞白血病（ATL）与1型人类T细胞白血病病毒感染有关。肿瘤抑制基因肺癌1（TSLC1）先前被鉴定为ATL的一种新型细胞表面标志物，本研究证明了TSLC1表达与ATL细胞的肿瘤生长和器官浸润有关。在使用NOD/SCID/γc（null）小鼠的实验中，TSLC1高表达的白血病细胞系和原发性ATL细胞均导致更多的肿瘤形成以及对小鼠各器官的侵袭性浸润。我们的结果表明，ATL细胞中TSLC1的表达在ATL细胞的生长和器官浸润中起重要作用。
