Yıldırım Ayhan, Kösem Mustafa, Sayar Ilyas, Gelincik Ibrahim, Yavuz Alparslan, Bozkurt Aliseydi, Erkorkmaz Unal, Bayram Irfan
Department of Pathology, Diyarbakır Pediatry and Gynecology Hospital Diyarbakır, Turkey.
Department of Pathology, Sakarya University Sakarya, Turkey.
Int J Clin Exp Med. 2014 Jun 15;7(6):1516-23. eCollection 2014.
In the present study, the intention was to reveal the relationship of histological grade and stage with c-erbB2, CD44s, and PCNA immunoreactivity in bladder urothelial carcinomas (UC). In our study, we evaluated 46 items of transurethral resection material of patients submitted by YYU Faculty of Medicine, Main Department of Pathology, with a mass revealed in their bladder after clinical and radiological studies at our laboratories and who were diagnosed with urothelial carcinomas. PCNA, c-erbB2, and CD44s were applied in an immunohistochemical manner comprised from nine low-malignant potential papillary urothelial neoplasia, 23 low-grade papillary urothelial carcinoma, and 14 high-grade papillary urothelial carcinoma. Immunostaining was scored according to the percentage of positive cells. The immunohistochemical study demonstrated that the c-erbB2 and PCNA staining ratio increased when an increase occurred in stage and grade. The CD44s staining ratio decreased. C-erbB2, PCNA, and CD44s appear to be a useful marker in the assessment of the prognosis and treatment options in urothelial carcinomas.
在本研究中，目的是揭示膀胱尿路上皮癌（UC）的组织学分级和分期与c-erbB2、CD44s和PCNA免疫反应性之间的关系。在我们的研究中，我们评估了YYU医学院病理学主要科室提交的46例经尿道切除材料，这些患者在我们实验室经过临床和放射学检查后膀胱发现肿物，并被诊断为尿路上皮癌。PCNA、c-erbB2和CD44s以免疫组织化学方法应用于9例低恶性潜能乳头状尿路上皮肿瘤、23例低级别乳头状尿路上皮癌和14例高级别乳头状尿路上皮癌。根据阳性细胞百分比对免疫染色进行评分。免疫组织化学研究表明，随着分期和分级的增加，c-erbB2和PCNA染色率升高，CD44s染色率降低。C-erbB2、PCNA和CD44s似乎是评估尿路上皮癌预后和治疗选择的有用标志物。
