Wannfors K, Hammarström L
Department of Oral Pathology, Karolinska Institutet, School of Dentistry, Huddinge, Sweden.
Int J Oral Maxillofac Surg. 1989 Jun;18(3):179-83. doi: 10.1016/s0901-5027(89)80122-5.
In order to provide a better understanding of the reactions of bone affected by an infectious stimulus, infected dental roots were implanted into the mandibular bone of 5 monkeys (Macaca fascicularis). The roots were infected by micro-organisms belonging to the monkeys' oral plaque flora. Following an observation period of 6 months, the monkeys were sacrificed. The mandibles were dissected. Radiographs were taken and then the mandibles were prepared for histology. In the mandibles where the infected roots had been implanted, advanced inflammatory changes were seen. Bacteria, however, were only found within the implanted roots, not in the surrounding tissue in spite of a heavy inflammatory reaction. The interaction between infection and inflammation is discussed on the basis of these observations. The role of possible neural transmittor substances in the pathogenesis of the inflammatory disease is also discussed. The signs and symptoms of the proliferative inflammatory changes provoked in this experiment are compared to those of chronic osteomyelitis.
为了更好地了解受感染刺激影响的骨骼反应，将受感染的牙根植入5只猕猴（食蟹猴）的下颌骨中。这些牙根被属于猕猴口腔菌斑菌群的微生物感染。经过6个月的观察期后，处死猕猴。解剖下颌骨，拍摄X线片，然后将下颌骨制备用于组织学检查。在植入了受感染牙根的下颌骨中，可见进展性炎症变化。然而，尽管有严重的炎症反应，但仅在植入的牙根内发现细菌，而在周围组织中未发现。基于这些观察结果讨论了感染与炎症之间的相互作用。还讨论了可能的神经递质物质在炎症性疾病发病机制中的作用。将本实验中引发的增殖性炎症变化的体征和症状与慢性骨髓炎的体征和症状进行了比较。
