Lewey Jennifer, Haythe Jennifer
Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY.
Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY.
Semin Perinatol. 2014 Aug;38(5):309-17. doi: 10.1053/j.semperi.2014.04.021. Epub 2014 Jun 5.
Cardiomyopathy during pregnancy is uncommon but potentially catastrophic to maternal health, accounting for up to 11% of maternal deaths. Peripartum cardiomyopathy is diagnosed in women without a history of heart disease 1 month before delivery or within 5 months postpartum. About half of all women will have full myocardial recovery within 6 months of diagnosis, but complications such as severe heart failure or death are not rare. African-American women have higher rates of diagnosis and adverse events. Women with preexisting cardiomyopathy, such as dilated or hypertrophic cardiomyopathy, followed closely during pregnancy often tolerate pregnancy and delivery. Risk factors for adverse outcomes include functional status at baseline, severity of systolic dysfunction or outflow tract gradient, or history of prior cardiac event, such as arrhythmia or stroke. The level of brain natriuretic peptide (BNP) can be used to risk stratify women for adverse events. Pregnant women with cardiomyopathy should be followed closely by a multidisciplinary team comprised of nurses, obstetricians, neonatologists, cardiologists, anesthesiologists, and cardiac surgeons.
妊娠期心肌病并不常见,但对孕产妇健康可能具有灾难性影响,占孕产妇死亡人数的11%。围产期心肌病是指在分娩前1个月或产后5个月内,既往无心脏病史的女性被诊断出患有心肌病。大约一半的女性在确诊后6个月内心肌会完全恢复,但严重心力衰竭或死亡等并发症并不罕见。非裔美国女性的诊断率和不良事件发生率较高。患有如扩张型或肥厚型心肌病等原有心肌病的女性,孕期密切随访通常能耐受妊娠和分娩。不良结局的危险因素包括基线功能状态、收缩功能障碍或流出道梯度的严重程度,或既往心脏事件史,如心律失常或中风。脑钠肽(BNP)水平可用于对女性不良事件进行风险分层。患有心肌病的孕妇应由护士、产科医生、新生儿科医生、心脏病专家、麻醉师和心脏外科医生组成的多学科团队密切随访。