Malebranche Rodolphe, Tabou Moyo Christian, Morisset Paul-Henry, Raphael Nernst-Atwood, Wilentz James Robert
Cardiology Unit, Department of Medicine, Hospital of the University of the State of Haiti, Port-au-Prince, Haiti; Faculty of Medicine and Pharmacy of the University of the State of Haiti, Port-au-Prince, Haiti.
Cardiology Unit, Department of Medicine, Hospital of the University of the State of Haiti, Port-au-Prince, Haiti.
Am Heart J. 2016 Aug;178:151-60. doi: 10.1016/j.ahj.2016.06.001. Epub 2016 Jun 7.
This study aimed to evaluate the clinical and epidemiologic profile of congestive heart failure at the principal free-care hospital in Haiti. Cardiovascular disease represents the most prevalent cause of admissions to the medical service of the University Hospital of the State of Haiti. No previous study has examined the demographics of congestive heart failure in urban Haiti.
Two hundred forty-seven patients presented to the inpatient service between May 2011 and May 2013. Evaluation included history and physical, CBC, renal/metabolic profile, serum glucose, anti-HIV antibody, ECG, chest radiograph and echocardiogram. Treatment included angiotensin converting enzyme inhibitors, furosemide and spironolactone, carvedilol, digoxin and anticoagulation.
Women (62.4%) outnumbered men; patients were relatively young (mean age 50.1) and from the lowest socio-economic levels of the population. Nearly all (98.8%) presented with NYHA III-IV status, with correspondingly high mortality (23.3%). Echocardiography showed 73% dilated cardiomyopathy; 83% showed moderate to severe LV systolic dysfunction (mean EF 36.5 +/- 15%) and 17% preserved LV systolic function. The three principal etiologies were dilated cardiomyopathy (29%) hypertensive cardiomyopathy (27%) and peripartum cardiomyopathy (20%). Ischemic cardiomyopathy was rare (3.4%). At 27 months follow-up, 76.7% of the patients were alive and well. Among those who died, mean survival time was 113 days. Readmission carried a poor prognosis.
This congestive heart failure study from Haiti shows an unusually high proportion of young women, primarily due to peripartum cardiomyopathy. Ischemic cardiomyopathy is rare, as in Africa. Further study is warranted to address the particular problem of the high frequency of peripartum cardiomyopathy in this population.
本研究旨在评估海地主要免费医疗医院中充血性心力衰竭的临床和流行病学特征。心血管疾病是海地国立大学医院内科住院患者最常见的病因。此前尚无研究调查过海地城市地区充血性心力衰竭患者的人口统计学特征。
2011年5月至2013年5月期间,共有247例患者入住该院。评估内容包括病史及体格检查、全血细胞计数、肾/代谢指标、血糖、抗HIV抗体、心电图、胸部X线片及超声心动图。治疗措施包括使用血管紧张素转换酶抑制剂、呋塞米和螺内酯、卡维地洛、地高辛及抗凝治疗。
女性患者(62.4%)多于男性;患者相对年轻(平均年龄50.1岁),且来自社会经济水平最低的人群。几乎所有患者(98.8%)心功能分级为纽约心脏病协会(NYHA)III-IV级,死亡率相应较高(23.3%)。超声心动图显示73%为扩张型心肌病;83%表现为中度至重度左心室收缩功能障碍(平均射血分数36.5±15%),17%左心室收缩功能正常。三个主要病因分别为扩张型心肌病(29%)、高血压性心肌病(27%)和围产期心肌病(20%)。缺血性心肌病罕见(3.4%)。随访27个月时,76.7%的患者存活且情况良好。死亡患者的平均生存时间为113天。再次入院预后较差。
这项来自海地的充血性心力衰竭研究表明,年轻女性比例异常高,主要原因是围产期心肌病。与非洲情况一样,缺血性心肌病罕见。有必要进一步研究该人群中围产期心肌病高发这一特殊问题。