French Catherine A, Fisher Simon E
Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal.
Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Curr Opin Neurobiol. 2014 Oct;28:72-9. doi: 10.1016/j.conb.2014.07.003. Epub 2014 Jul 19.
Disruptions of the FOXP2 gene cause a rare speech and language disorder, a discovery that has opened up novel avenues for investigating the relevant neural pathways. FOXP2 shows remarkably high conservation of sequence and neural expression in diverse vertebrates, suggesting that studies in other species are useful in elucidating its functions. Here we describe how investigations of mice that carry disruptions of Foxp2 provide insights at multiple levels: molecules, cells, circuits and behaviour. Work thus far has implicated the gene in key processes including neurite outgrowth, synaptic plasticity, sensorimotor integration and motor-skill learning.
FOXP2基因的破坏会导致一种罕见的言语和语言障碍，这一发现为研究相关神经通路开辟了新途径。FOXP2在多种脊椎动物中显示出序列和神经表达的高度保守性，这表明在其他物种中进行的研究有助于阐明其功能。在这里，我们描述了对携带Foxp2基因破坏的小鼠的研究如何在多个层面提供见解：分子、细胞、神经回路和行为。迄今为止的研究表明，该基因参与了包括神经突生长、突触可塑性、感觉运动整合和运动技能学习在内的关键过程。
