臭黄荆树皮甲醇提取物对大鼠的初步药理活性
Preliminary pharmacological activity of the methanolic extract of Premna integrifolia barks in rats.
作者信息
Khatun Hajera, Majumder Rajib, Alam Efte Kharul, Jami Safkath Ibne, Alam Badrul
机构信息
Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh.
出版信息
Avicenna J Phytomed. 2014 May;4(3):215-24.
OBJECTIVE
Premna integrifolia Linn (Family: Verbenaceae) synonym of Premna serratifolia has tremendous medicinal value. Preliminary pharmacological studies were performed on the methanolic extract of Premna integrifolia (MEPI) bark to investigate neuropharmacological, analgesic, and anti-inflammatory activities.
MATERIALS AND METHODS
Neuropharmacology study was done by open field and hole cross test whereas acetic acid writhing test and formalin induced pain was done for analgesic activity of MEPI. Carrageenan induced inflammatory model was considered for anti-inflammatory activity evaluation.
RESULTS
A statistically significant (p0.05) decrease in locomotor activity was observed at all doses in the open-field and hole-cross tests. The extract significantly (p0.05) and dose dependently reduced the writhing reflex in the acetic acid-induced writhing test as well as licking response in the formalin induced inflammatory pain. At 200 mg/kg body weight dose, MEPI showed 71.16% inhibition in carrageenan induced anti-inflammatory activity.
CONCLUSION
The finding of this study suggests that MEPI will provide scientific support for the use of this species in traditional medicine.
目的
假茉莉（马鞭草科），即锯齿叶豆腐柴的同义词，具有巨大的药用价值。对假茉莉树皮的甲醇提取物（MEPI）进行了初步药理研究，以探讨其神经药理学、镇痛和抗炎活性。
材料与方法
通过旷场试验和穿洞试验进行神经药理学研究，而通过醋酸扭体试验和福尔马林诱导的疼痛试验来评估MEPI的镇痛活性。采用角叉菜胶诱导的炎症模型来评估抗炎活性。
结果
在旷场试验和穿洞试验中，所有剂量下均观察到运动活性有统计学意义的显著降低（p<0.05）。在醋酸诱导的扭体试验中，该提取物显著（p<0.05）且剂量依赖性地降低了扭体反射，在福尔马林诱导的炎性疼痛试验中也降低了舔舐反应。在200mg/kg体重剂量下，MEPI对角叉菜胶诱导的抗炎活性表现出71.16%的抑制作用。
结论
本研究结果表明，MEPI将为该物种在传统医学中的应用提供科学依据。
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