Adzu B, Amos S, Kapu S D, Gamaniel K S
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, PMB 21, Garki, Abuja, Nigeria.
J Ethnopharmacol. 2003 Feb;84(2-3):169-73. doi: 10.1016/s0378-8741(02)00295-7.
Sphaeranthus senegalensis Vaill (Asteraceae) is used in traditional medicine as a remedy for rheumatic pains and other ailments. The anti-inflammatory and anti-nociceptive activity of the aqueous extract of the whole shoot of the plant was evaluated in mice and rats. Activity of the extract against egg-albumin induced hind paw oedema was measured to evaluate the anti-inflammatory activity while the anti-nociceptive potency was evaluated using three painful stimuli viz acetic acid induced abdominal constriction and hot plate test in mice, and the formalin test in rats. Results indicated that the extract possess remarkable dose dependent anti-inflammatory activities in rats. The extract also showed anti-nociceptive activities against acetic acid induced writhing, formalin and the hot plate pain models. The effects were significant (P < 0.05) when compared with the saline control group. The results suggest the presence of a potent anti-inflammatory and anti-nociceptive principle in the extract, which support the folkloric use of the plant in relieving rheumatic pains.
塞内加尔金纽扣（菊科）在传统医学中被用作治疗风湿疼痛和其他疾病的药物。对该植物全株水提取物在小鼠和大鼠中的抗炎和抗伤害感受活性进行了评估。通过测量提取物对蛋清诱导的后爪水肿的活性来评估其抗炎活性，同时使用三种疼痛刺激来评估抗伤害感受能力，即小鼠中的醋酸诱导腹部收缩和热板试验，以及大鼠中的福尔马林试验。结果表明，该提取物在大鼠中具有显著的剂量依赖性抗炎活性。该提取物对醋酸诱导的扭体、福尔马林和热板疼痛模型也显示出抗伤害感受活性。与生理盐水对照组相比，效果显著（P < 0.05）。结果表明提取物中存在一种有效的抗炎和抗伤害感受成分，这支持了该植物在缓解风湿疼痛方面的民间应用。
Zotero 插件