Voduc Nha, la Porte Charles, Tessier Caroline, Mallick Ranjeeta, Cameron D William
a Department of Medicine, Division of Respirology, University of Ottawa at The Ottawa Hospital, General Campus, 501 Smyth Road, Box 211, Ottawa, ON K1H 8L6, Canada.
Appl Physiol Nutr Metab. 2014 Oct;39(10):1183-7. doi: 10.1139/apnm-2013-0547. Epub 2014 Apr 30.
To assess the effect on exercise capacity and tolerability of resveratrol, 13 healthy, sedentary adult volunteers were enrolled in a randomized crossover study comparing resveratrol and placebo over two 4-week periods, with a 2-week time between periods when subjects received no treatment. No significant changes in exercise duration or aerobic capacity (peak oxygen uptake) were observed. Gastrointestinal side effects were more common during resveratrol treatment (77% vs. 15%, p = 0.0048). A small reduction in fasting glucose and small but statistically significant increases in liver enzymes, total cholesterol, and triglycerides were observed, although mean results remained within normal limits. There was no change in complete blood count, inflammatory markers, renal function, or other measures of liver function.
为评估白藜芦醇对运动能力和耐受性的影响，13名健康的久坐成年志愿者参与了一项随机交叉研究，在两个为期4周的时间段内比较白藜芦醇和安慰剂，两个时间段之间有2周的无治疗期。未观察到运动持续时间或有氧能力（峰值摄氧量）有显著变化。白藜芦醇治疗期间胃肠道副作用更常见（77%对15%，p = 0.0048）。观察到空腹血糖略有降低，肝酶、总胆固醇和甘油三酯有小幅但具有统计学意义的升高，尽管平均结果仍在正常范围内。全血细胞计数、炎症标志物、肾功能或其他肝功能指标均无变化。
