Scribbans Trisha D, Ma Jasmin K, Edgett Brittany A, Vorobej Kira A, Mitchell Andrew S, Zelt Jason G E, Simpson Craig A, Quadrilatero Joe, Gurd Brendon J
a School of Kinesiology and Health Studies, Queen's University, Kingston, ON K7L 3N6, Canada.
Appl Physiol Nutr Metab. 2014 Nov;39(11):1305-13. doi: 10.1139/apnm-2014-0070. Epub 2014 Jul 23.
The present study examined the effect of concurrent exercise training and daily resveratrol (RSV) supplementation (150 mg) on training-induced adaptations following low-dose high-intensity interval training (HIIT). Sixteen recreationally active (∼22 years, ∼51 mL·kg(-1)·min(-1)) men were randomly assigned in a double-blind fashion to either the RSV or placebo group with both groups performing 4 weeks of HIIT 3 days per week. Before and after training, participants had a resting muscle biopsy taken, completed a peak oxygen uptake test, a Wingate test, and a submaximal exercise test. A main effect of training (p < 0.05) and interaction effect (p < 0.05) on peak aerobic power was observed; post hoc pairwise comparisons revealed that a significant (p < 0.05) increase occurred in the placebo group only. Main effects of training (p < 0.05) were observed for both peak oxygen uptake (placebo - pretraining: 51.3 ± 1.8, post-training: 54.5 ± 1.5 mL·kg(-1)·min(-1), effect size (ES) = 0.93; RSV - pretraining: 49.6 ± 2.2, post-training: 52.3 ± 2.5 mL·kg(-1)·min(-1), ES = 0.50) and Wingate peak power (placebo: pretraining: 747 ± 39, post-training: 809 ± 31 W, ES = 0.84; RSV - pretraining: 679 ± 39, post-training: 691 ± 43 W, ES = 0.12). Fibre-type distribution was unchanged, while a main effect of training (p < 0.05) was observed for succinate dehydrogenase activity and glycogen content, but not α-glycerophosphate dehydrogenase activity or intramuscular lipids in type I and IIA fibres. The fold change in PGC-1α, SIRT1, and SOD2 gene expression following training was significantly (p < 0.05) lower in the RSV group than placebo. These results suggest that concurrent exercise training and RSV supplementation may alter the normal training response induced by low-volume HIIT.
本研究考察了同时进行运动训练和每日补充白藜芦醇（RSV，150毫克）对低剂量高强度间歇训练（HIIT）后训练适应性的影响。16名有运动习惯的男性（约22岁，约51毫升·千克⁻¹·分钟⁻¹）被随机双盲分配到RSV组或安慰剂组，两组均每周进行3天、为期4周的HIIT。在训练前后，参与者进行了静息肌肉活检，完成了峰值摄氧量测试、温盖特测试和次最大运动测试。观察到训练对峰值有氧功率有主效应（p<0.05）和交互效应（p<0.05）；事后两两比较显示，仅安慰剂组出现显著（p<0.05）增加。在峰值摄氧量（安慰剂 - 训练前：51.3±1.8，训练后：54.5±1.5毫升·千克⁻¹·分钟⁻¹，效应量（ES）=0.93；RSV - 训练前：49.6±2.2，训练后：52.3±2.5毫升·千克⁻¹·分钟⁻¹，ES = 0.50）和温盖特峰值功率（安慰剂：训练前：747±39，训练后：809±31瓦，ES = 0.84；RSV - 训练前：679±39，训练后：691±43瓦，ES = 0.12）方面均观察到训练的主效应。纤维类型分布未改变，而观察到训练对琥珀酸脱氢酶活性和糖原含量有主效应（p<0.05），但对I型和IIA型纤维中的α - 甘油磷酸脱氢酶活性或肌内脂质无主效应。训练后RSV组中PGC - 1α、SIRT1和SOD2基因表达的倍数变化显著（p<0.05）低于安慰剂组。这些结果表明，同时进行运动训练和补充RSV可能会改变低容量HIIT诱导的正常训练反应。
