功能性震颤患者的触觉和本体感觉时间辨别能力受损。
Tactile and proprioceptive temporal discrimination are impaired in functional tremor.
作者信息
Tinazzi Michele, Fasano Alfonso, Peretti Alessia, Bove Francesco, Conte Antonella, Dallocchio Carlo, Arbasino Carla, Defazio Giovanni, Fiorio Mirta, Berardelli Alfredo
机构信息
Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.
Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
出版信息
PLoS One. 2014 Jul 22;9(7):e102328. doi: 10.1371/journal.pone.0102328. eCollection 2014.
BACKGROUND AND METHODS
In order to obtain further information on the pathophysiology of functional tremor, we assessed tactile discrimination threshold and proprioceptive temporal discrimination motor threshold values in 11 patients with functional tremor, 11 age- and sex-matched patients with essential tremor and 13 healthy controls.
RESULTS
Tactile discrimination threshold in both the right and left side was significantly higher in patients with functional tremor than in the other groups. Proprioceptive temporal discrimination threshold for both right and left side was significantly higher in patients with functional and essential tremor than in healthy controls. No significant correlation between discrimination thresholds and duration or severity of tremor was found.
CONCLUSIONS
Temporal processing of tactile and proprioceptive stimuli is impaired in patients with functional tremor. The mechanisms underlying this impaired somatosensory processing and possible ways to apply these findings clinically merit further research.
背景与方法
为了获取关于功能性震颤病理生理学的更多信息，我们评估了11例功能性震颤患者、11例年龄和性别匹配的特发性震颤患者以及13名健康对照者的触觉辨别阈值和本体感觉时间辨别运动阈值。
结果
功能性震颤患者双侧的触觉辨别阈值显著高于其他组。功能性震颤和特发性震颤患者双侧的本体感觉时间辨别阈值显著高于健康对照者。未发现辨别阈值与震颤持续时间或严重程度之间存在显著相关性。
结论
功能性震颤患者对触觉和本体感觉刺激的时间处理受损。这种体感处理受损的潜在机制以及将这些发现应用于临床的可能方法值得进一步研究。
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