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曲妥珠单抗偶联脂质体包被的荧光磁性纳米颗粒用于靶向乳腺癌。

Trastuzumab-conjugated liposome-coated fluorescent magnetic nanoparticles to target breast cancer.

作者信息

Jang Mijung, Yoon Young Il, Kwon Yong Soo, Yoon Tae-Jong, Lee Hak Jong, Hwang Sung Il, Yun Bo La, Kim Sun Mi

机构信息

Department of Radiology, Seoul National University Bundang Hospital, Seongnam 463-707, Korea.

Nanoimaging and Therapy Research Center, Institute of Nanoconvergence, Advanced Institutes of Convergence Technology, Seoul National University, Suwon 443-270, Korea.

出版信息

Korean J Radiol. 2014 Jul-Aug;15(4):411-22. doi: 10.3348/kjr.2014.15.4.411. Epub 2014 Jul 9.

DOI:10.3348/kjr.2014.15.4.411
PMID:25053899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4105802/
Abstract

OBJECTIVE: To synthesize mesoporous silica-core-shell magnetic nanoparticles (MNPs) encapsulated by liposomes (Lipo [MNP@m-SiO2]) in order to enhance their stability, allow them to be used in any buffer solution, and to produce trastuzumab-conjugated (Lipo[MNP@m-SiO2]-Her2Ab) nanoparticles to be utilized in vitro for the targeting of breast cancer. MATERIALS AND METHODS: The physiochemical characteristics of Lipo[MNP@m-SiO2] were assessed in terms of size, morphological features, and in vitro safety. The multimodal imaging properties of the organic dye incorporated into Lipo[MNP@m-SiO2] were assessed with both in vitro fluorescence and MR imaging. The specific targeting ability of trastuzumab (Her2/neu antibody, Herceptin®)-conjugated Lipo[MNP@m-SiO2] for Her2/neu-positive breast cancer cells was also evaluated with fluorescence and MR imaging. RESULTS: We obtained uniformly-sized and evenly distributed Lipo[MNP@m-SiO2] that demonstrated biological stability, while not disrupting cell viability. Her2/neu-positive breast cancer cell targeting by trastuzumab-conjugated Lipo[MNP@m-SiO2] was observed by in vitro fluorescence and MR imaging. CONCLUSION: Trastuzumab-conjugated Lipo[MNP@m-SiO2] is a potential treatment tool for targeted drug delivery in Her2/neu-positive breast cancer.

摘要

目的：合成脂质体包裹的介孔二氧化硅核壳磁性纳米颗粒（MNPs，脂质体[MNP@m-SiO2]），以提高其稳定性，使其能在任何缓冲溶液中使用，并制备曲妥珠单抗偶联的（脂质体[MNP@m-SiO2]-Her2Ab）纳米颗粒用于体外靶向乳腺癌。 材料与方法：从尺寸、形态特征和体外安全性方面评估脂质体[MNP@m-SiO2]的理化特性。通过体外荧光和磁共振成像评估掺入脂质体[MNP@m-SiO2]的有机染料的多模态成像特性。还用荧光和磁共振成像评估曲妥珠单抗（Her2/neu抗体，赫赛汀®）偶联的脂质体[MNP@m-SiO2]对Her2/neu阳性乳腺癌细胞的特异性靶向能力。 结果：我们获得了尺寸均匀且分布均匀的脂质体[MNP@m-SiO2]，其具有生物稳定性，同时不破坏细胞活力。通过体外荧光和磁共振成像观察到曲妥珠单抗偶联的脂质体[MNP@m-SiO2]对Her2/neu阳性乳腺癌细胞的靶向作用。 结论：曲妥珠单抗偶联的脂质体[MNP@m-SiO2]是Her2/neu阳性乳腺癌靶向药物递送的潜在治疗工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f64/4105802/69a6734b2aaf/kjr-15-411-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f64/4105802/5afc2bd5927c/kjr-15-411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f64/4105802/ba78e1c86df9/kjr-15-411-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f64/4105802/a372012ebbed/kjr-15-411-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f64/4105802/e18010ac09b5/kjr-15-411-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f64/4105802/69a6734b2aaf/kjr-15-411-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f64/4105802/5afc2bd5927c/kjr-15-411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f64/4105802/ba78e1c86df9/kjr-15-411-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f64/4105802/a372012ebbed/kjr-15-411-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f64/4105802/e18010ac09b5/kjr-15-411-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f64/4105802/69a6734b2aaf/kjr-15-411-g006.jpg

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