[从1852年命名的北亚高纬度地区的白氏硬蜱（硬蜱属）中分离出的鄂霍次克病毒（OKHV）和阿尼瓦病毒（ANIV）（环状病毒属，呼肠孤病毒科）的分子遗传学特征]
[Molecular-genetic characterization of the Okhotskiy virus (OKHV) and Aniva virus (ANIV) (Orbivirus, Reoviridae) isolated from the ticks Ixodes (Ceratixodes) uriae White, 1852 in high latitudes of the Northern Eurasia].
作者信息
L'vov D K, Al'khovskiĭ S V, Shchelkanov M Iu, Shchetinin A M, Deriabin P G, Gitel'man A K, Samokhvalov E I, Botikov A G
出版信息
Vopr Virusol. 2014 Mar-Apr;59(2):22-8.
Molecular-genetic characteristics of the Okhotskiy virus (OKHV) and Aniva virus (ANIV) were studied (ID GenBank KF981623-32). These viruses are distributed over the shelf and Island areas in the high latitudes in the Okhotsk, Bering, and Barents seas and linked with nesting colonies of Alcidae seabirds and their obligatory parasites, the Ixodes uriae (Ixodidae) ticks. OKHV and ANIV are observed to be independent species within the limits of the Great Island virus (GIV) group of the Orbivirus genus of the Reoviridae family. The majority of the genes of OKHV and ANIV have high homology (VP1 - 96%, T2 - 99%, VP7 (T13) - 98%, NS1 - 94%, NS2 - 98%, NS3 - 72%, VP6 - 93%). Nevertheless, the envelope proteins containing the main specific antigenic determinants (VP2 and VP5) of OKHV and ANIV are sufficiently different (62% and 68% homology for amino acid sequences, respectively).
对鄂霍次克病毒（OKHV）和阿尼瓦病毒（ANIV）的分子遗传学特征进行了研究（基因库登录号KF981623 - 32）。这些病毒分布在鄂霍次克海、白令海和巴伦支海高纬度地区的大陆架和岛屿区域，与海雀科海鸟的筑巢群落及其专性寄生虫——尿蜱（硬蜱科）有关。在呼肠孤病毒科正呼肠孤病毒属的大岛病毒（GIV）组范围内，OKHV和ANIV被观察到是独立的物种。OKHV和ANIV的大多数基因具有高度同源性（VP1 - 96%，T2 - 99%，VP7（T13） - 98%，NS1 - 94%，NS2 - 98%，NS3 - 72%，VP6 - 93%）。然而，包含OKHV和ANIV主要特异性抗原决定簇的包膜蛋白（VP2和VP5）差异很大（氨基酸序列同源性分别为62%和68%）。
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