我们对髓系调节细胞的认识演变：从髓源性抑制细胞到Mregs。
Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs.
作者信息
Manjili Masoud H, Wang Xiang-Yang, Abrams Scott
机构信息
Department of Microbiology and Immunology, Virginia Commonwealth University , Richmond, VA , USA ; Massey Cancer Center, Virginia Commonwealth University , Richmond, VA , USA.
Massey Cancer Center, Virginia Commonwealth University , Richmond, VA , USA ; Department of Human and Molecular Genetics, Virginia Commonwealth University , Richmond, VA , USA.
出版信息
Front Immunol. 2014 Jul 2;5:303. doi: 10.3389/fimmu.2014.00303. eCollection 2014.
The term myeloid-derived suppressor cells (MDSCs) was first suggested in 2007 in order to reflect the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions. Emerging evidence suggests that MDSCs suppress CTL and Th1 responses in malignant diseases while they regulate effective immune responses in parasitic and helminth infections as well as Th17 inflammatory response during autoimmune diseases. Based on these data, the term myeloid regulatory cells (Mregs) more accurately reflects their function and interactions with different cells of the immune system during diseased conditions. Here, we provide evidence on the multifaceted function of Mregs during diseased states.
髓源性抑制细胞（MDSCs）这一术语于2007年首次被提出，以反映在癌症及其他病理状况下免疫抑制过程中髓系细胞的起源和功能。新出现的证据表明，MDSCs在恶性疾病中抑制细胞毒性T淋巴细胞（CTL）和Th1反应，而在寄生虫和蠕虫感染中调节有效的免疫反应，以及在自身免疫性疾病中调节Th17炎症反应。基于这些数据，髓系调节细胞（Mregs）这一术语更准确地反映了它们在疾病状态下的功能以及与免疫系统不同细胞的相互作用。在此，我们提供了关于Mregs在疾病状态下多方面功能的证据。
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