Vera Elena, Iorgulescu J Bryan, Raper Daniel M S, Madhavan Karthik, Lally Brian E, Morcos Jacques, Elhammady Samy, Sherman Jonathan, Komotar Ricardo J
Department of Anesthesiology, University of Texas Medical Center, Houston, Texas, United States.
Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, United States.
J Neurol Surg B Skull Base. 2014 Jun;75(3):152-8. doi: 10.1055/s-0033-1354747. Epub 2014 Mar 12.
Gross total resection of skull base meningiomas poses a surgical challenge due to their proximity to neurovascular structures. Once the gold standard therapy for skull base meningiomas, microsurgery has been gradually replaced by or used in combination with stereotactic radiosurgery (SRS). This review surveys the safety and efficacy of SRS in the treatment of cranial base meningiomas including 36 articles from 1991 to 2010. SRS produces excellent tumor control with low morbidity rates compared with surgery alone for asymptomatic small skull base meningiomas, patients with risk factors precluding conventional surgery, and as adjuvant therapy for recurrent or residual lesions.
由于颅底脑膜瘤靠近神经血管结构,因此其全切除手术具有挑战性。显微手术曾经是颅底脑膜瘤的金标准治疗方法,但现已逐渐被立体定向放射外科(SRS)取代或与之联合使用。本综述调查了SRS治疗颅底脑膜瘤的安全性和有效性,涵盖了1991年至2010年的36篇文章。对于无症状的小型颅底脑膜瘤、存在排除传统手术的危险因素的患者以及作为复发性或残留性病变的辅助治疗,与单纯手术相比,SRS能实现出色的肿瘤控制,且发病率较低。