Jakobsson A, Swiezewska E, Chojnacki T, Dallner G
Department of Biochemistry, University of Stockholm, Sweden.
FEBS Lett. 1989 Sep 11;255(1):32-6. doi: 10.1016/0014-5793(89)81055-5.
Short and long dolichols and polyprenols in free form or esterified with fatty acids were incorporated into liposomes and administered to rats through a gastric tube. The free alcohols were taken up by the liver to different extents. While uptake in other organs was less, it also involved the fatty acid esters. The use of systems other than liposomes did not increase the efficiency of uptake. Most of the administered lipids were recovered in the lysosomes. Exogenous dolichols and polyprenols were both partly esterified in the liver and, to some extent, also phosphorylated; a portion of the polyprenols was also alpha-saturated. These results indicate that various polyisoprenes are taken up, to a small extent, from the diet by tissues under normal conditions and in liver these dietary lipids undergo terminal modifications.
游离形式或与脂肪酸酯化的短链和长链多萜醇及聚戊烯醇被包裹在脂质体中，并通过胃管给大鼠给药。游离醇在肝脏中的摄取程度各不相同。虽然在其他器官中的摄取较少，但也涉及脂肪酸酯。使用脂质体以外的系统并没有提高摄取效率。大部分给药的脂质在溶酶体中被回收。外源性多萜醇和聚戊烯醇在肝脏中都有部分被酯化，并且在一定程度上也被磷酸化；一部分聚戊烯醇还被α-饱和。这些结果表明，在正常情况下，各种聚异戊二烯在一定程度上会被组织从饮食中摄取，并且在肝脏中这些饮食脂质会经历末端修饰。
