Zohora Umme Salma, Rahman Mohammad Shahedur, Khan Abdul Wahab, Okanami Masahiro, Ano Takashi
Proximo Biotech, 1-50 Newtown, Dinajpur 5200, Bangladesh.
Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8503, Japan; Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Jahangirnagar University, Savar 1342, Dhaka, Bangladesh.
J Environ Sci (China). 2013 Dec;25 Suppl 1:S2-7. doi: 10.1016/S1001-0742(14)60616-1.
To enhance the production of lipopeptide antibiotic iturin A, nutrient contents of the culture mediums were investigated in both submerged and biofilm fermentations. As a carbon source maltose and as nitrogen source, fish protein was used. In submerged fermentation maltose uptake was found lower (12%) compared to biofilm fermentation (15%) that was associated with higher cellular growth in biofilm. However, requirement of nitrogen (fish protein) concentration was found similar in both submerged and biofilm fermentations. Production of iturin A in submerged fermentation with 12% maltose and 5% fish protein was 4450 mg/L, and in biofilm fermentation it was 5050 mg/L when 15% maltose and 5% fish protein was used.
为提高脂肽抗生素伊枯草菌素A的产量，在深层发酵和生物膜发酵中对培养基的营养成分进行了研究。使用麦芽糖作为碳源，鱼蛋白作为氮源。在深层发酵中，发现麦芽糖的摄取量（12%）低于生物膜发酵（15%），这与生物膜中较高的细胞生长有关。然而，在深层发酵和生物膜发酵中，氮（鱼蛋白）浓度的需求相似。在使用12%麦芽糖和5%鱼蛋白的深层发酵中，伊枯草菌素A的产量为4450毫克/升，而在生物膜发酵中，当使用15%麦芽糖和5%鱼蛋白时，产量为5050毫克/升。
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