Department of Biotechnology, KLE Technological University, Hubballi 580031, Karnataka, India.
Department of Physics, B. V Bhoomaraddi College of Engineering and Technology, Hubballi 580031, Karnataka, India.
Biomolecules. 2023 Oct 12;13(10):1515. doi: 10.3390/biom13101515.
This comprehensive review examines iturin, a cyclic lipopeptide originating from and related bacteria. These compounds are structurally diverse and possess potent inhibitory effects against plant disease-causing bacteria and fungi. Notably, Iturin A exhibits strong antifungal properties and low toxicity, making it valuable for bio-pesticides and mycosis treatment. Emerging research reveals additional capabilities, including anticancer and hemolytic features. Iturin finds applications across industries. In food, iturin as a biosurfactant serves beyond surface tension reduction, enhancing emulsions and texture. Biosurfactants are significant in soil remediation, agriculture, wound healing, and sustainability. They also show promise in Microbial Enhanced Oil Recovery (MEOR) in the petroleum industry. The pharmaceutical and cosmetic industries recognize iturin's diverse properties, such as antibacterial, antifungal, antiviral, anticancer, and anti-obesity effects. Cosmetic applications span emulsification, anti-wrinkle, and antibacterial use. Understanding iturin's structure, synthesis, and applications gains importance as biosurfactant and lipopeptide research advances. This review focuses on emphasizing iturin's structural characteristics, production methods, biological effects, and applications across industries. It probes iturin's antibacterial, antifungal potential, antiviral efficacy, and cancer treatment capabilities. It explores diverse applications in food, petroleum, pharmaceuticals, and cosmetics, considering recent developments, challenges, and prospects.
这篇全面的综述考察了iturin，一种源自 和相关细菌的环状脂肽。这些化合物结构多样，对引起植物病害的细菌和真菌具有强大的抑制作用。特别是iturin A 具有很强的抗真菌特性和低毒性，使其成为有价值的生物农药和真菌病治疗药物。新兴的研究揭示了其额外的特性，包括抗癌和溶血特性。iturin 在各个行业都有应用。在食品领域，iturin 作为一种生物表面活性剂，除了降低表面张力外，还能增强乳液和质地。生物表面活性剂在土壤修复、农业、伤口愈合和可持续发展方面具有重要意义。它们在石油工业中的微生物强化采油（MEOR）中也有应用前景。制药和化妆品行业认识到iturin 的多种特性，如抗菌、抗真菌、抗病毒、抗癌和抗肥胖作用。化妆品应用涵盖乳化、抗皱和抗菌用途。随着生物表面活性剂和脂肽研究的进展，了解 iturin 的结构、合成和应用变得越来越重要。本综述重点强调了 iturin 的结构特征、生产方法、生物效应以及在各个行业的应用。探讨了它的抗菌、抗真菌潜力、抗病毒效果以及癌症治疗能力。还研究了它在食品、石油、制药和化妆品方面的多种应用，考虑了最近的发展、挑战和前景。
