Ferrer Calvete J, Ribes Koninckx C, Quiles Durá J L, Sala Lizárraga J
Departamento de Pediatría, Hospital Infantil La Fe, Valencia.
An Esp Pediatr. 1989 Jul;31(1):30-2.
110 children suffering from malabsorption underwent several biopsies of the gut to confirm coeliac disease (CD) following the ESPGAN criteria. We studied the values for alkaline phosphatase (AP) in the intestinal mucosa after gluten challenge. In 42 patients the after challenge biopsy was normal, thus excluding coeliac disease. In 68 children the mucosa was severely damaged confirming CD. In all biopsy specimens lactase, invertase, maltase and alkaline phosphatase were measured. We found a good correlation between PA values and severity of mucosal damage, showing that measurement of PA in the mucosa is helpful in assessing the degree of mucosal atrophy in children suffering from malabsorption.
110名患有吸收不良的儿童按照欧洲儿科胃肠病学、肝病学和营养学会（ESPGAN）标准接受了多次肠道活检以确诊乳糜泻（CD）。我们研究了麸质激发试验后肠黏膜中碱性磷酸酶（AP）的值。42例患者激发试验后的活检结果正常，从而排除了乳糜泻。68名儿童的黏膜严重受损，确诊为CD。在所有活检标本中测量了乳糖酶、蔗糖酶、麦芽糖酶和碱性磷酸酶。我们发现碱性磷酸酶值与黏膜损伤严重程度之间存在良好的相关性，表明测量黏膜中的碱性磷酸酶有助于评估患有吸收不良的儿童的黏膜萎缩程度。
