373例乳糜泻患者的肠道乳糖酶、蔗糖酶和碱性磷酸酶
Intestinal lactase, sucrase, and alkaline phosphatase in 373 patients with coeliac disease.
作者信息
O'Grady J G, Stevens F M, Keane R, Cryan E M, Egan-Mitchell B, McNicholl B, McCarthy C F, Fottrell P F
出版信息
J Clin Pathol. 1984 Mar;37(3):298-301. doi: 10.1136/jcp.37.3.298.
Abstract
Lactase, sucrase, and alkaline phosphatase activities were measured in 833 peroral small intestinal biopsies from 373 patients with coeliac disease. Enzyme activities decreased with increasing degrees of mucosal damage. Enzyme activities in mucosae of patients with coeliac disease in remission were lower than in control groups matched for age, sex, and site of biopsy. Enzyme activities were measured in 81 patients when the mucosa was severely damaged and later when considerable improvement had occurred. Lactase activity remained low in 13% of patients under the age of 18 and in 33% of those over 18 years. Sucrase activity usually improved with histological recovery, but alkaline phosphatase activity tended to remain depressed in patients in whom lactase activity failed to improve.
摘要
对373例乳糜泻患者的833份经口小肠活检样本进行了乳糖酶、蔗糖酶和碱性磷酸酶活性检测。酶活性随黏膜损伤程度的加重而降低。缓解期乳糜泻患者黏膜中的酶活性低于年龄、性别和活检部位相匹配的对照组。对81例患者在黏膜严重受损时及之后出现显著改善时进行了酶活性检测。18岁以下患者中13%的乳糖酶活性持续较低，18岁以上患者中这一比例为33%。蔗糖酶活性通常随组织学恢复而改善，但乳糖酶活性未改善的患者碱性磷酸酶活性往往仍处于较低水平。
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