Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; Graduate Institute of Business and Management, Chang Gung University, Taoyuan, Taiwan.
Department of Information Management, Chang Gung University, Taoyuan, Taiwan.
Ann Thorac Surg. 2014 Sep;98(3):1013-9. doi: 10.1016/j.athoracsur.2014.05.012. Epub 2014 Jul 29.
Although large cell neuroendocrine carcinoma (LCNEC) and lymphoepithelioma-like carcinoma (LELC) are the variants of large cell carcinoma (LCC) of lung, there are few studies comparing them. The aim of this study was to compare the clinical characteristic and treatment outcomes of LCNEC, LELC, and classic LCC.
Patients with LCNEC, LELC, or classic LCC were identified in a prospectively collected database, and their data were analyzed.
A total of 46 patients with classic LCC, 30 with LCNEC, and 18 with LELC, who received surgical resection with curative intent, were identified and included in the analysis. Patients with LELC were younger, and the frequency of nonsmokers was greater than in patients with classic LCC or LCNEC. In patients with LCNEC or LELC, most lesions were located on the left side. There were 5 surgical deaths, and the median follow-up time of the surviving patients was 44.1 months. The 5-year disease free survival among the three subgroups was similar (p = 0.601), but patients with LELC had a significantly better overall survival than the other two subgroups (LELC vs classic LCC, p = 0.009; LELC vs LCNEC, p = 0.002). Multivariate analysis showed tumor location site, tumor stage, and LELC were independent prognostic factors of overall survival.
The clinical manifestations and treatment outcomes of LCNEC, LELC, and classic LCC are different. LCNEC has a poor survival, and survival is not different than that of classic LCC. LELC is associated with younger age and a higher frequency of nonsmokers, and the treatment outcomes are better than those of other subtypes.
虽然大细胞神经内分泌癌（LCNEC）和淋巴上皮样癌（LELC）是肺大细胞癌（LCC）的变体，但比较它们的研究很少。本研究旨在比较 LCNEC、LELC 和经典 LCC 的临床特征和治疗结果。
在一个前瞻性收集的数据库中确定了 LCNEC、LELC 或经典 LCC 的患者，并对其数据进行了分析。
共纳入 46 例接受根治性手术治疗的经典 LCC 患者、30 例 LCNEC 患者和 18 例 LELC 患者，并进行了分析。LELC 患者年龄较小，非吸烟者的比例高于经典 LCC 或 LCNEC 患者。在 LCNEC 或 LELC 患者中，大多数病变位于左侧。有 5 例手术死亡，存活患者的中位随访时间为 44.1 个月。三组患者的 5 年无病生存率相似（p = 0.601），但 LELC 患者的总生存率明显优于其他两组（LELC 与经典 LCC，p = 0.009；LELC 与 LCNEC，p = 0.002）。多因素分析表明肿瘤部位、肿瘤分期和 LELC 是总生存的独立预后因素。
LCNEC、LELC 和经典 LCC 的临床表现和治疗结果不同。LCNEC 的生存率较差，与经典 LCC 无差异。LELC 与年轻和非吸烟的频率较高有关，治疗结果优于其他亚型。
