U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, USA.
U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, USA.
J Chromatogr A. 2014 Sep 12;1359:140-6. doi: 10.1016/j.chroma.2014.07.032. Epub 2014 Jul 19.
A method was developed and validated for the determination of 16 prostaglandin analogs in cosmetic products. The QuEChERS (Quick, Easy, Cheap, Efficient, Rugged, Safe) liquid-liquid extraction method, typically used for pesticide residue analysis, was utilized as the sample preparation technique. The prostaglandin analogs were chromatographically separated and quantified using high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). Thirty-one cosmetic products were surveyed, and 13 products were determined to contain a prostaglandin analog with amounts ranging from 27.4 to 297μg/g. The calculated concentrations for the cosmetic products were in a similar range when compared to the concentrations of three different prostaglandin analog-containing prescription products.
建立并验证了一种测定化妆品中 16 种前列腺素类似物的方法。本研究采用 QuEChERS（Quick, Easy, Cheap, Efficient, Rugged, Safe）液液萃取法作为样品前处理技术，该方法通常用于农药残留分析。采用高效液相色谱-串联质谱法（HPLC-MS/MS）对前列腺素类似物进行色谱分离和定量。本研究调查了 31 种化妆品，其中 13 种产品被检出含有前列腺素类似物，含量为 27.4 至 297μg/g。与三种含有不同前列腺素类似物的处方产品相比，所计算出的化妆品浓度处于相似的范围内。
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