采用QuEChERS（快速、简便、廉价、有效、耐用且安全）方法开发并验证一种用于测定动物组织中兽药残留的多类液相色谱串联质谱（LC-MS/MS）方法。
The development and validation of a multiclass liquid chromatography tandem mass spectrometry (LC-MS/MS) procedure for the determination of veterinary drug residues in animal tissue using a QuEChERS (QUick, Easy, CHeap, Effective, Rugged and Safe) approach.
作者信息
Stubbings George, Bigwood Timothy
机构信息
Central Science Laboratory, Sand Hutton, York, YO41 1LZ, UK.
出版信息
Anal Chim Acta. 2009 Apr 1;637(1-2):68-78. doi: 10.1016/j.aca.2009.01.029. Epub 2009 Jan 22.
A novel rapid multiresidue/multiclass procedure with liquid chromatography tandem mass spectrometry (LC-MS/MS) detection has been developed to screen for the presence of veterinary drug residues in animal tissues. The method uses a new sample preparation procedure loosely based on QuEChERS (QUick, Easy, CHeap, Effective, Rugged and Safe) methodology. Validation to date has been restricted to chicken muscle and has been performed according to European Commission guidelines [COMMISSION DECISION of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results] for nitroimidazoles, sulphonamides, fluoroquinolones, quinolones, ionophores and dinitrocarbanilide. Recent work has shown that the method is also applicable to macrolide and lincosamide antibiotics, benzimidazoles, levamisole, avermectins and tranquillisers.
已开发出一种采用液相色谱串联质谱（LC-MS/MS）检测的新型快速多残留/多类别方法，用于筛查动物组织中兽药残留的存在情况。该方法采用了一种新的样品制备程序，该程序大致基于QuEChERS（快速、简便、廉价、有效、耐用且安全）方法。迄今为止，验证仅限于鸡肉，并且已根据欧盟委员会指南[2002年8月12日实施理事会指令96/23/EC关于分析方法的性能和结果解释的委员会决定]对硝基咪唑类、磺胺类、氟喹诺酮类、喹诺酮类、离子载体类和二硝基甲酰胺类进行了验证。最近的研究表明，该方法也适用于大环内酯类和林可酰胺类抗生素、苯并咪唑类、左旋咪唑、阿维菌素类和镇静剂。
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