Katakawa Kazuaki, Sato Ayaka, Iwasaki Mari, Horikawa Tomofumi, Kumamoto Takuya
Department of Synthetic Organic Chemistry, Research Institute of Pharmaceutical Sciences, Musashino University.
Chem Pharm Bull (Tokyo). 2014;62(8):820-3. doi: 10.1248/cpb.c14-00228.
We describe the total synthesis of angular chromenoquinone 1 isolated from Conospermum plants. Iodophenol, a precursor of pyranobenzyne, was prepared by Claisen rearrangement of an iodoresorcinol derivative. Diels-Alder reaction of the pyranobenzyne and a substituted furan proceeded in low regioselectivity to afford desired 1 and its regioisomer.
我们描述了从锥果檀属植物中分离得到的角型色满醌1的全合成。碘苯酚作为吡喃苯炔的前体，通过碘间苯二酚衍生物的克莱森重排制备。吡喃苯炔与取代呋喃的狄尔斯-阿尔德反应区域选择性较低，得到所需的1及其区域异构体。
