Firth James D, Craven Philip G E, Lilburn Matthew, Pahl Axel, Marsden Stephen P, Nelson Adam
School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
Max Planck Institute of Molecular Physiology, Otto-Hahn Strasse 11, 44227 Dortmund, Germany.
Chem Commun (Camb). 2016 Jul 28;52(63):9837-40. doi: 10.1039/c6cc04662b.
A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels-Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.
受二萜生物合成的启发，开发了一种合成多种支架的方法。最初使用呋喃基官能化胺的狄尔斯-阿尔德反应生成的支架，通过裂解、扩环、环化和重排反应转化为其他支架。总共制备了25种不同的支架，这些支架显示出与天然产物高度相似的特性。
