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用于叶酸受体特异性可激活成像和光动力治疗的智能双功能弹头

Smart dual-functional warhead for folate receptor-specific activatable imaging and photodynamic therapy.

作者信息

Kim Jisu, Tung Ching-Hsuan, Choi Yongdoo

机构信息

Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769, Korea.

出版信息

Chem Commun (Camb). 2014 Sep 21;50(73):10600-3. doi: 10.1039/c4cc04166f. Epub 2014 Aug 4.

DOI:10.1039/c4cc04166f
PMID:25089302
Abstract

A smart dual-targeted theranostic agent becomes highly fluorescent and phototoxic only when its linker is cleaved by tumor-associated lysosomal enzyme cathepsin B after internalization into folate receptor-positive cancer cells.

摘要

一种智能双靶向诊疗试剂只有在被内化进入叶酸受体阳性癌细胞后，其连接子被肿瘤相关溶酶体酶组织蛋白酶B切割时，才会变得具有高荧光性和光毒性。

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