一种用于改善局部光动力疗法的叶酸共轭二氧化硅 - 二氧化钛多孔空心纳米球。
A folic acid conjugated silica-titania porous hollow nanosphere for improved topical photodynamic therapy.
作者信息
Jang Yoonsun, Kim Sojin, Oh Wan-Kyu, Kim Chanhoi, Lee Inkyu, Jang Jyongsik
机构信息
World Class University (WCU) Program of Chemical Convergence for Energy & Environment (C2E2) School of Chemical and Biological Engineering, College of Engineering, Seoul National University (SNU), Seoul, Korea.
出版信息
Chem Commun (Camb). 2014 Dec 18;50(97):15345-7. doi: 10.1039/c4cc07457b. Epub 2014 Oct 28.
The folic acid conjugated hollow nanosphere is used to encapsulate protoporphyrin IX and is utilized for photodynamic therapy. This system represents a 3.33 times higher photodynamic efficiency than previous protoporphyrin IX-based systems. The result proposes a new opportunity for effective photodynamic therapy of folate receptor positive tumor cells.
叶酸共轭空心纳米球用于包裹原卟啉IX，并用于光动力治疗。该系统的光动力效率比以前基于原卟啉IX的系统高3.33倍。该结果为叶酸受体阳性肿瘤细胞的有效光动力治疗提供了新的机会。
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