在脂多糖（LPS）和2-巯基乙醇（2-ME）存在的情况下，钙离子载体A23187对胸腺细胞的刺激作用：关于A23187和2-ME的作用方式
Stimulation of thymus cells by the calcium ionophore A23187 in the presence of LPS and 2-ME: on the mode of action of A23187 and 2-ME.
作者信息
Burger M
机构信息
Institute of Pathology, University of Bern, Switzerland.
出版信息
Immunol Lett. 1989 Sep;22(3):183-5. doi: 10.1016/0165-2478(89)90187-9.
PMID:2509331
Abstract
The stimulation of murine spleen and thymus cells by the calcium ionophore A23187 was studied using a serum-free culture technique. In cultures of spleen cells, rabbit IgG was capable of replacing A23187 in bringing about the stimulation of cells. Low concentrations of A23187 were inhibitory to proliferating B lymphocytes. In cultures of thymus cells a stimulating activity of A23187 was observed only if LPS was present in the medium.
摘要
采用无血清培养技术研究了钙离子载体A23187对小鼠脾细胞和胸腺细胞的刺激作用。在脾细胞培养中，兔IgG能够替代A23187刺激细胞。低浓度的A23187对增殖的B淋巴细胞有抑制作用。在胸腺细胞培养中，只有当培养基中存在LPS时，才观察到A23187的刺激活性。
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