铜催化需氧氧化惰性碳-碳和碳-氮键裂解：合成叔酰胺的新策略。
Copper-catalyzed aerobic oxidative inert C-C and C-N bond cleavage: a new strategy for the synthesis of tertiary amides.
作者信息
Chen Xiuling, Chen Tieqiao, Li Qiang, Zhou Yongbo, Han Li-Biao, Yin Shuang-Feng
机构信息
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410081 (P. R. China), Fax: (+86) 731-88821171.
出版信息
Chemistry. 2014 Sep 15;20(38):12234-8. doi: 10.1002/chem.201403144. Epub 2014 Aug 5.
A copper-catalyzed aerobic oxidative amidation reaction of inert C-C bonds with tertiary amines has been developed for the synthesis of tertiary amides, which are significant units in many natural products, pharmaceuticals, and fine chemicals. This method combines C-C bond activation, C-N bond cleavage, and C-H bond oxygenation in a one-pot protocol, using molecular oxygen as the sole oxidant without any additional ligands.
已开发出一种铜催化的惰性碳-碳键与叔胺的需氧氧化酰胺化反应，用于合成叔酰胺，叔酰胺是许多天然产物、药物和精细化学品中的重要结构单元。该方法在一锅法中结合了碳-碳键活化、碳-氮键裂解和碳-氢键氧化，使用分子氧作为唯一氧化剂，无需任何额外配体。
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