Cheng Hui-Cheng, Hou Wen-Jun, Li Zeng-Wen, Liu Ming-Yu, Guan Bing-Tao
State Key Laboratory and Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China.
Chem Commun (Camb). 2015 Dec 25;51(99):17596-9. doi: 10.1039/c5cc07454a.
A general and efficient method for the synthesis of tertiary amides has been developed via the copper-catalyzed aerobic oxidative amidation of tertiary amines. Due to the use of the O2 oxidant, various functional groups were well tolerated under the present conditions. Extensive substrates studies demonstrated its potential as a practical approach for the synthesis of tertiary amides.
通过铜催化叔胺的有氧氧化酰胺化反应，开发了一种通用且高效的合成叔酰胺的方法。由于使用了氧气作为氧化剂，在当前条件下各种官能团都能很好地耐受。广泛的底物研究证明了其作为合成叔酰胺的实用方法的潜力。
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