SAMHD1 在 HIV 限制中的新活性。
A new activity for SAMHD1 in HIV restriction.
机构信息
Gladstone Institute of Virology and Immunology and the University of California-San Francisco, San Francisco, California, USA.
出版信息
Nat Med. 2014 Aug;20(8):808-9. doi: 10.1038/nm.3657.
DOI:10.1038/nm.3657
PMID:25100520
Abstract
Restriction factors are host cell proteins that inhibit retroviral infection. A new study using mutants of human HIV-1 restriction factor SAMHD1 suggests that it inhibits infection through degradation of viral RNA rather than through its dNTPase activity as previously suggested.
摘要
限制因子是宿主细胞蛋白，可抑制逆转录病毒感染。一项新的研究使用人 HIV-1 限制因子 SAMHD1 的突变体表明，它通过降解病毒 RNA 而不是通过先前建议的 dNTPase 活性来抑制感染。
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