Department of Physical Medicine and Rehabilitation, Bağcilar Training and Research Hospital Istanbul, Turkey.
Institute of Biomedical Engineering, Fatih University Istanbul, Turkey.
Front Hum Neurosci. 2014 Jul 18;8:536. doi: 10.3389/fnhum.2014.00536. eCollection 2014.
High rate stimulations of the neuromuscular system, such as continuous whole body vibration, tonic vibration reflex and high frequency electrical stimulation, are used in the physiological research with an increasing interest. In these studies, the neuronal circuitries underlying the reflex responses remain unclear due to the problem of determining the exact reflex latencies. We present a novel "cumulated average method" to determine the reflex latency during high rate stimulation of the nervous system which was proven to be significantly more accurate than the classical method. The classical method, cumulant density analysis, reveals the relationship between the two synchronously recorded signals as a function of the lag between the signals. The comparison of new method with the classical technique and their relative accuracy was tested using a computer simulation. In the simulated signals the EMG response latency was constructed to be exactly 40 ms. The new method accurately indicated the value of the simulated reflex latency (40 ms). However, the classical method showed that the lag time between the simulated triggers and the simulated signals was 49 ms. Simulation results illustrated that the cumulated average method is a reliable and more accurate method compared with the classical method. We therefore suggest that the new cumulated average method is able to determine the high rate stimulation induced reflex latencies more accurately than the classical method.
高频率刺激神经肌肉系统，如持续全身振动、紧张性振动反射和高频电刺激，在生理研究中受到越来越多的关注。在这些研究中，由于确定确切反射潜伏期的问题，反射反应的神经元回路仍然不清楚。我们提出了一种新的“累积平均方法”来确定神经系统高频率刺激时的反射潜伏期，该方法被证明比经典方法更准确。经典方法，累积密度分析，揭示了两个同时记录的信号之间的关系作为信号之间的滞后的函数。使用计算机模拟测试了新方法与经典技术及其相对准确性的比较。在模拟信号中，肌电图反应潜伏期被构建为正好 40 毫秒。新方法准确地指示了模拟反射潜伏期（40ms）的值。然而，经典方法显示模拟触发信号和模拟信号之间的滞后时间为 49ms。模拟结果表明，与经典方法相比，累积平均方法是一种可靠且更准确的方法。因此，我们建议新的累积平均方法比经典方法更能准确地确定高频刺激引起的反射潜伏期。
