Department of Nuclear Medicine, Dalin Tzu Chi General Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan ; School of Medicine, Tzu Chi University, Hualian, Taiwan.
Department of Pharmacy, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.
Int J Endocrinol. 2014;2014:138653. doi: 10.1155/2014/138653. Epub 2014 Jul 1.
Vascular events are one of the major causes of death in case of Cushing's syndrome (CS). However, due to the relative low frequency of CS, it is hard to perform a risk assessment for these events. As represented congestive heart failure (C), hypertension (H), age (A), diabetes (D), and stroke (S), the CHADS2 score is now accepted to classify the risk of major adverse cardiovascular events (MACEs) in patients with atrial fibrillation. In this study, participants were enrolled from the National Health Research Institute Database (NHIRD) of Taiwan, and we reviewed 551 patients with their sequential clinically diagnosed CS data between 2002 and 2009 in relation to MACEs risk using CHADS2 score. Good correlation could be identified between the CS and CHADS2 score (AUC = 0.795). Our results show that patients with CS show significantly higher risk of vascular events and the CHADS2 score could be applied for MACEs evaluation. Adequate lifestyle modifications and aggressive cardiovascular risks treatment are suggested for CS patients with higher CHADS2 score.
血管事件是库欣综合征（CS）患者死亡的主要原因之一。然而，由于 CS 的相对低频率，很难对这些事件进行风险评估。CHADS2 评分代表充血性心力衰竭（C）、高血压（H）、年龄（A）、糖尿病（D）和中风（S），现在被用于分类心房颤动患者发生主要不良心血管事件（MACEs）的风险。在这项研究中，参与者是从台湾国家健康研究研究所数据库（NHIRD）中招募的，我们回顾了 2002 年至 2009 年期间 551 例连续临床诊断为 CS 的患者的数据，使用 CHADS2 评分评估其发生 MACEs 的风险。CS 与 CHADS2 评分之间存在良好的相关性（AUC=0.795）。我们的结果表明，CS 患者发生血管事件的风险显著增加，CHADS2 评分可用于评估 MACEs。建议 CHADS2 评分较高的 CS 患者进行适当的生活方式改变和积极的心血管风险治疗。
