孕早期超声检测单脐动脉：其作为胎儿畸形标志物的价值。
Detection of single umbilical artery in the first trimester ultrasound: its value as a marker of fetal malformation.
作者信息
Martínez-Payo Cristina, Cabezas Elena, Nieto Yolanda, Ruiz de Azúa Miguel, García-Benasach Fátima, Iglesias Enrique
机构信息
Department of Obstetrics and Gynecology, Prenatal Diagnosis Unit, University Hospital Puerta de Hierro-Majadahonda, C/Manuel de Falla N°1, Majadahonda, 28222 Madrid, Spain.
出版信息
Biomed Res Int. 2014;2014:548729. doi: 10.1155/2014/548729. Epub 2014 Jul 3.
INTRODUCTION
The value of a single umbilical artery (SUA) in first trimester ultrasound is not well established. The aim of our study was to determinate the relevance of diagnosis of single umbilical artery in first trimester ultrasound as an early marker suggesting the presence of malformations or associated chromosomopathies.
MATERIAL AND METHODS
Retrospective study of clinical cases of SUA diagnosed at the University Hospital Puerta de Hierro in Madrid (Spain) during the first trimester ultrasound between September 2008 and September 2012.
RESULTS
Prevalence of SUA was 1.1% in single pregnancies and 3.3% in twin pregnancies. Sensitivity, specificity, false positive rate, and false negative rate for the finding in the first trimester were 84.2, 99.8, 0.2, and 15.7%, respectively. 17.6% of cases had associated malformations. With an ultrasound in the 16th week most of the cases with significant fetal malformation were diagnosed.
DISCUSSION
SUA is a useful marker in the first trimester for fetal malformation pathology, as it will allow detecting a large number of cases with malformations before 20 weeks of gestation.
引言
早孕期超声检查中单一脐动脉（SUA）的价值尚未明确确立。我们研究的目的是确定早孕期超声诊断单一脐动脉作为提示存在畸形或相关染色体病的早期标志物的相关性。
材料与方法
对2008年9月至2012年9月期间在西班牙马德里Puerta de Hierro大学医院早孕期超声诊断为SUA的临床病例进行回顾性研究。
结果
单胎妊娠中SUA的患病率为1.1%，双胎妊娠中为3.3%。早孕期该发现的敏感性、特异性、假阳性率和假阴性率分别为84.2%、99.8%、0.2%和15.7%。17.6%的病例伴有相关畸形。在孕16周进行超声检查时，大多数有严重胎儿畸形的病例得以诊断。
讨论
SUA是早孕期胎儿畸形病理学的一个有用标志物，因为它能在妊娠20周前检测出大量有畸形的病例。
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