微小RNA：癌症诊断与治疗中的新角色。
MicroRNAs: novel players in cancer diagnosis and therapies.
作者信息
Oom Aaron L, Humphries Brock A, Yang Chengfeng
机构信息
Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Department of Physiology, Michigan State University, East Lansing, MI 48824, USA ; Cellular and Molecular Biology Graduate Program, Michigan State University, East Lansing, MI 48824, USA.
出版信息
Biomed Res Int. 2014;2014:959461. doi: 10.1155/2014/959461. Epub 2014 Jul 2.
Abstract
First discovered in 1993, microRNAs (miRNAs) have been one of the hottest research areas over the past two decades. Oftentimes, miRNAs levels are found to be dysregulated in cancer patients. The potential use of miRNAs in cancer therapies is an emerging and promising field, with research finding miRNAs to play a role in cancer initiation, tumor growth, and metastasis. Therefore, miRNAs could become an integral part from cancer diagnosis to treatment in future. This review aims to examine current novel research work on the potential roles of miRNAs in cancer therapies, while also discussing several current challenges and needed future research.
摘要
微小RNA（miRNA）于1993年首次被发现，在过去二十年中一直是最热门的研究领域之一。通常情况下，人们发现癌症患者体内的miRNA水平失调。miRNA在癌症治疗中的潜在应用是一个新兴且有前景的领域，研究发现miRNA在癌症的发生、肿瘤生长和转移中发挥作用。因此，miRNA未来可能会成为癌症诊断到治疗中不可或缺的一部分。这篇综述旨在探讨目前关于miRNA在癌症治疗中潜在作用的新研究工作，同时也讨论当前的一些挑战以及未来所需的研究。
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