经颅直流电刺激左右背外侧前额叶皮质：对计划表现及相关眼动的侧化效应。
Transcranial direct current stimulation over left and right DLPFC: Lateralized effects on planning performance and related eye movements.
作者信息
Heinze Katharina, Ruh Nina, Nitschke Kai, Reis Janine, Fritsch Brita, Unterrainer Josef M, Rahm Benjamin, Weiller Cornelius, Kaller Christoph P
机构信息
Department of Neurology, University Medical Center Freiburg, Germany; Freiburg Brain Imaging Center, University of Freiburg, Germany; Biological and Personality Psychology, Department of Psychology, University of Freiburg, Germany; Cochlear Implant Center Erlangen, ENT Department, University Hospital Erlangen, Germany.
Department of Neurology, University Medical Center Freiburg, Germany; Freiburg Brain Imaging Center, University of Freiburg, Germany; Biological and Personality Psychology, Department of Psychology, University of Freiburg, Germany.
出版信息
Biol Psychol. 2014 Oct;102:130-40. doi: 10.1016/j.biopsycho.2014.07.019. Epub 2014 Aug 4.
Left and right dorsolateral prefrontal cortex (dlPFC) were recently found to be differentially affected by unilateral continuous theta-burst stimulation, reflected in an oppositional alteration of initial thinking time (ITT) in the Tower of London planning task. Here, we further explored this finding using bilateral transcranial direct current stimulation (tDCS) and simultaneous tracking of eye movements. Results revealed a decrease in ITT during concurrent cathodal tDCS of left dlPFC and anodal tDCS of right dlPFC. Eye-movement analyses showed that this facilitating tDCS effect was associated with the actual planning phase, thus reflecting a planning-specific impact of stimulation. For the reverse stimulation pattern of cathodal tDCS of right dlPFC and anodal tDCS of left dlPFC, an increase in gaze shifts was observed, without a significant impact on ITT. Taken together, these findings corroborate that enhanced planning performance can be obtained by boosting right dlPFC and dismantling the inhibitory impact of left dlPFC.
最近发现，左右背外侧前额叶皮层（dlPFC）受到单侧连续theta爆发刺激的影响不同，这反映在伦敦塔计划任务中初始思考时间（ITT）的相反变化上。在此，我们使用双侧经颅直流电刺激（tDCS）并同时跟踪眼动进一步探究了这一发现。结果显示，在左侧dlPFC阴极tDCS和右侧dlPFC阳极tDCS同时进行期间，ITT减少。眼动分析表明，这种促进性tDCS效应与实际计划阶段相关，从而反映了刺激对计划的特定影响。对于右侧dlPFC阴极tDCS和左侧dlPFC阳极tDCS的反向刺激模式，观察到注视转移增加，但对ITT没有显著影响。综上所述，这些发现证实，通过增强右侧dlPFC并消除左侧dlPFC的抑制作用，可以提高计划表现。
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