Rymal Eric, Rizzolo Denise
Eric Rymal practices physical medicine in Hampton Roads, Va., managing acute and chronic musculoskeletal conditions. Denise Rizzolo is an associate professor in the PA program at Seton Hall University in South Orange, N.J., an assistant clinical professor in the PA program at Pace University in New York City, and practices urgent care in Springfield, N.J.The authors have disclosed no potential conflicts of interest, financial or otherwise.
JAAPA. 2014 Sep;27(9):26-31. doi: 10.1097/01.JAA.0000453233.24754.ec.
The prevalence of gout in the US population is steadily increasing. Genome-wide research has found several variants of DNA sequences that predispose patients to irregular uric acid metabolism. Comorbidities linked to gout include obesity and cardiovascular disease. Though the formal diagnosis is made with arthrocentesis and subsequent analysis, CT and ultrasound findings supplement the diagnosis and monitor disease management. Newer immunologic agents are available for patients whose disease is refractory to standard therapy.
痛风在美国人群中的患病率正在稳步上升。全基因组研究发现了几种DNA序列变体，这些变体使患者易患尿酸代谢异常。与痛风相关的合并症包括肥胖和心血管疾病。虽然通过关节穿刺术及后续分析进行正式诊断，但CT和超声检查结果可辅助诊断并监测疾病管理情况。对于疾病对标准治疗无效的患者，有更新的免疫制剂可供使用。
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