在印度患者中，与蛋白酶抑制剂治疗失败相关的HIV-1 C亚型中，新型四肽插入Gag-p6 ALIX结合基序。
Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.
作者信息
Neogi Ujjwal, Rao Shwetha D, Bontell Irene, Verheyen Jens, Rao Vasudev R, Gore Sagar C, Soni Neelesh, Shet Anita, Schülter Eugen, Ekstrand Maria L, Wondwossen Amogne, Kaiser Rolf, Madhusudhan Mallur S, Prasad Vinayaka R, Sonnerborg Anders
机构信息
aDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden bDivision of Public Health and Infection, St. John's Research Institute, Bangalore India cUnit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden dInstitute of Virology, University-Hospital, University Duisburg-Essen, Essen, Germany eDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA fIndian Institute of Science Education and Research, Pune, Maharashtra, India gInstitute of Virology, University of Cologne, Cologne, Germany hDepartment of Medicine, University of California, San Francisco, California, USA iDepartment of Medicine, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia jBioinformatics Institute kDepartment of Biological Sciences, National University of Singapore, Singapore.
出版信息
AIDS. 2014 Sep 24;28(15):2319-22. doi: 10.1097/QAD.0000000000000419.
A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P < 0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.
在Gag-p6 ALIX结合区域发现了一种新的四肽插入，它出现在蛋白酶抑制剂治疗失败的印度HIV-1C序列中（优势比=17.1，P<0.001），但在一半未经治疗的埃塞俄比亚HIV-1C序列中自然存在。预计该插入可恢复HIV-1C中缺乏的ALIX介导的病毒释放途径。在蛋白酶抑制剂药物使用正在扩大的HIV-1C主导地区，需要评估该插入的临床重要性。
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