母亲体重指数对脐血促红细胞生成素浓度的影响。
Effect of maternal body mass index on cord blood erthropoietin concentrations.
作者信息
Barak S, Mimouni F B, Stern R, Cohen N, Marom R
机构信息
1] Department of Obstetrics and Gynecology, The Lis Maternity Hospital, Tel Aviv-Sourasky Medical Center, Tel Aviv, Israel [2] The Sackler School of Medicine, Tel Aviv, Israel.
1] The Sackler School of Medicine, Tel Aviv, Israel [2] Department of Neonatology, The Lis Maternity Hospital, Tel Aviv-Sourasky Medial Center, Tel Aviv, Israel.
出版信息
J Perinatol. 2015 Jan;35(1):29-31. doi: 10.1038/jp.2014.140. Epub 2014 Aug 7.
OBJECTIVE
To examine the hypothesis that maternal body mass index (BMI) (an index of maternal adiposity) correlates with cord blood concentrations of erythropoietin (EPO).
STUDY DESIGN
Cross-sectional cohort study of consecutively born singleton term healthy infants born to mothers with various BMIs. Excluded were infants with major factors known to be associated with a potential increase in fetal erythropoiesis. Prepregnancy maternal BMI was calculated from maternal recollection.
RESULT
There was a significant correlation between EPO concentrations and maternal BMI (R = 0.427, P = 0.007). This correlation remained significant in multiple stepwise regression analysis using the EPO concentration as the dependent variable, and maternal age, parity, gestational age and Apgar scores (1 or 5 min) as potential confounders.
CONCLUSION
Cord blood concentrations of EPO correlate with maternal BMI. We speculate that increasing maternal BMI may represent a relative hypoxic burden on the fetus.
目的
检验母亲体重指数（BMI）（母亲肥胖程度指标）与脐血促红细胞生成素（EPO）浓度相关的假设。
研究设计
对连续出生的、母亲BMI各异的单胎足月儿健康婴儿进行横断面队列研究。排除已知与胎儿红细胞生成潜在增加相关的主要因素的婴儿。孕前母亲BMI根据母亲回忆计算得出。
结果
EPO浓度与母亲BMI之间存在显著相关性（R = 0.427，P = 0.007）。在以EPO浓度为因变量、母亲年龄、产次、孕周和阿氏评分（1或5分钟）作为潜在混杂因素的多元逐步回归分析中，这种相关性仍然显著。
结论
脐血EPO浓度与母亲BMI相关。我们推测母亲BMI增加可能代表胎儿相对缺氧负担。
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