Gupta G, Gupta I, Suri V, Dhawan V, Ganguly N K
Department of Obstetrics and Gynecology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Int J Gynaecol Obstet. 2000 Oct;71(1):1-5. doi: 10.1016/s0020-7292(00)00241-1.
The estimation of cord blood erythropoietin in subjects with pre-eclampsia and eclampsia.
Erythropoietin was measured, using ELISA, in the cord blood of infants born to 83 mothers with pre-eclampsia, and 7 with eclampsia. Another 90 subjects with no evidence of pre-eclampsia or eclampsia were taken as control subjects. Maternal parity, gestational age, blood pressures, 24-h urine protein and Apgar scores of the infants delivered were also noted.
Cord blood erythropoietin levels were statistically significantly higher (P<0.001) in infants born to mothers with pre-eclampsia and eclampsia. There was a significant positive correlation (P<0.01) between cord blood erythropoietin levels and maternal blood pressure (systolic and diastolic) and albuminuria. A negative correlation (P<0.01) was observed with the birth weights of infants.
Pre-eclampsia and eclampsia are associated with higher levels of cord blood erythropoietin.
评估先兆子痫和子痫患者脐带血中促红细胞生成素的水平。
采用酶联免疫吸附测定法（ELISA）检测83例先兆子痫母亲和7例子痫母亲所分娩婴儿的脐带血中促红细胞生成素水平。另外选取90例无先兆子痫或子痫证据的受试者作为对照。记录产妇的产次、孕周、血压、24小时尿蛋白以及所分娩婴儿的阿氏评分。
先兆子痫和子痫母亲所分娩婴儿的脐带血促红细胞生成素水平在统计学上显著更高（P<0.001）。脐带血促红细胞生成素水平与母亲血压（收缩压和舒张压）及蛋白尿之间存在显著正相关（P<0.01）。与婴儿出生体重呈负相关（P<0.01）。
先兆子痫和子痫与脐带血促红细胞生成素水平升高有关。
