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优雅山蚂蝗碱，一种从优雅山蚂蝗叶子中提取的新型生物碱，具有潜在的单胺氧化酶抑制活性。

Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a potential monoamine oxidase inhibitor.

作者信息

Zhi Kang-Kang, Yang Zhong-Duo, Shi Dan-Feng, Yao Xiao-Jun, Wang Ming-Gang

机构信息

School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, PR China.

School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, PR China.

出版信息

Fitoterapia. 2014 Oct;98:160-5. doi: 10.1016/j.fitote.2014.07.022. Epub 2014 Aug 4.

DOI:10.1016/j.fitote.2014.07.022
PMID:25102471
Abstract

Desmodeleganine (1), a new potential monoamine oxidase inhibitor, along with three known alkaloids, bufotenin (2), hydroxy-N, N-dimethyltryptamine N(12)-oxide (3), 2-(5-methoxy-1H-indol-3-yl)-N, and N-dimethylethylamine (4) were isolated from the leaves of Desmodium elegans. Their structures were elucidated by IR, MS, 1D and 2D NMR spectra. 1 showed strong monoamine oxidase inhibitory activity with IC50 value of 13.92 ± 1.5 μM, when the IC50 value of iproniazid as a standard was 6.5 ± 0.5 μM. The molecular modeling was also performed to explore the binding mode of compounds 1, 2 at the active site of MAO-A and MAO-B.

摘要

从优雅山蚂蝗的叶子中分离出一种新的潜在单胺氧化酶抑制剂去甲墨蝶呤碱（1），以及三种已知生物碱，即蟾毒色胺（2）、羟基 - N，N - 二甲基色胺N(12)-氧化物（3）和2-(5 - 甲氧基 - 1H - 吲哚 - 3 - 基)-N，N - 二甲基乙胺（4）。通过红外光谱、质谱、一维和二维核磁共振光谱对它们的结构进行了阐明。当作为标准的异烟肼的IC50值为6.5±0.5 μM时，1表现出较强的单胺氧化酶抑制活性，IC50值为13.92±1.5 μM。还进行了分子模拟以探究化合物1、2在单胺氧化酶A和单胺氧化酶B活性位点的结合模式。

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