Yang Zhong-Duo, Zhang Yu, Zhao Wei-Hua, Shu Zong-Mei
Department of Pharmaceutical Engineering, School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, China.
Iran J Pharm Res. 2020 Spring;19(2):259-263. doi: 10.22037/ijpr.2020.1101051.
In the present study, nine compounds (-) were isolated from LGT-4 (an endophytic fungus from ) which was cultured in CYM Medium. Their structures were determined as 4-hydroxyphthalide (), Fumitremorgin C (), Ergosterol (), 3-(2-hydroxypropyl)-8-hydroxy-3,4- dihydroisocoumarin (), Cis-cyclo(-Ala--Pro) (), 6-Amino-3-(4-hydroxybenzyl)- 1,4-diazonane-2,5-dione (), Aspergillumarin B (), Deacetylisowortmin B (), and Entonaemin A () based on NMR spectral data, as well as comparing with previous literature data. This is the first report of the isolation of compounds - and - from genus. All compounds were tested for their monoamine oxidase and phosphoinositide 3-kinase (PI3Kα) inhibitory activities. Compound , showed moderate anti-monoamine oxidase activity with IC value of 35 μg/mL, 28 μg/mL, respectively. Compound showed PI3K inhibitory activity with IC value of 10.3 /mL.
在本研究中，从在CYM培养基中培养的LGT - 4（一种来自……的内生真菌）中分离出九种化合物（-）。根据核磁共振光谱数据，并与先前的文献数据进行比较，确定它们的结构分别为4 - 羟基苯酞（）、烟曲霉震颤素C（）、麦角甾醇（）、3 - （2 - 羟丙基）- 8 - 羟基 - 3,4 - 二氢异香豆素（）、顺式环（-丙氨酸 - -脯氨酸）（）、6 - 氨基 - 3 - （4 - 羟基苄基）- 1,4 - 二氮杂环壬烷 - 2,5 - 二酮（）、曲霉霉素B（）、去乙酰异麦芽米因B（）和内孢菌素A（）。这是首次从……属中分离出化合物 - 和 - 的报道。对所有化合物进行了单胺氧化酶和磷酸肌醇3 - 激酶（PI3Kα）抑制活性测试。化合物 ，分别显示出中等程度的抗单胺氧化酶活性，IC值分别为35μg/mL、28μg/mL。化合物 显示出PI3K抑制活性，IC值为10.3 /mL。
