利奥前列素对胃溃疡患者胃酸和碳酸氢盐分泌的影响。
Effect of rioprostil on the gastric acid and bicarbonate secretion in patients with gastric ulcer.
作者信息
Krastev Z, Deredjian S, Matincheva R, Spasova Z, Karakasheva V
机构信息
Clinic of Gastroenterology, Medical Academy, Sofia, Bulgaria.
出版信息
Scand J Gastroenterol Suppl. 1989;164:141-5. doi: 10.3109/00365528909091203.
This double-blind trial is undertaken to study the effect of rioprostil on the acid and bicarbonate secretion in patients with gastric ulcer. Pentagastrin stimulation is performed before treatment and 9-20 days after the onset of treatment. In the four patients treated with rioprostil, the bicarbonate secretion increases and the parietal volume secretion decreases (p less than 0.05). The eight patients treated with ranitidine do not show an increase in bicarbonate secretion, but the decrease of the basal acid secretion is more prominent. The index of stimulated bicarbonate secretion/maximal acid output increases by 40% in those who are treated with rioprostil. This may be due to an increase in the cytoprotective activity and to a decrease in the aggressive activity of the gastric juice by rioprostil.
本双盲试验旨在研究利奥前列素对胃溃疡患者胃酸和碳酸氢盐分泌的影响。在治疗前以及治疗开始后9 - 20天进行五肽胃泌素刺激试验。在接受利奥前列素治疗的4例患者中，碳酸氢盐分泌增加，壁细胞容量分泌减少（P<0.05）。接受雷尼替丁治疗的8例患者碳酸氢盐分泌未增加，但基础胃酸分泌减少更为显著。接受利奥前列素治疗的患者刺激后碳酸氢盐分泌/最大胃酸分泌指数增加了40%。这可能是由于利奥前列素增强了细胞保护活性并降低了胃液的攻击活性。
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