Takayama Hiromitsu
Graduate School of Pharmaceutical Sciences, Chiba University.
Chem Pharm Bull (Tokyo). 2020;68(2):103-116. doi: 10.1248/cpb.c19-00872.
The merits of biogenetic considerations in the chemical syntheses of natural products have been emphasized by describing the total syntheses of Lycopodium alkaloids; lycodine, flabellidine, lycopodine, and flabelliformine, as well as monoterpenoid indole alkaloids; C-mavacurine, kopsiyunnanine K, koumine, and 11-methoxy-19R-hydroxygelselegine.
通过描述石松生物碱(石松定、扇叶石松定、石松碱和扇叶石松碱)以及单萜吲哚生物碱(C-马瓦库林、云南柯蒲木碱K、钩吻素子和11-甲氧基-19R-羟基格氏千里光碱)的全合成,强调了生物遗传学考虑在天然产物化学合成中的优点。