基于生物合成启发策略的石松类和单萜吲哚生物碱的全合成
Total Syntheses of Lycopodium and Monoterpenoid Indole Alkaloids Based on Biosynthesis-Inspired Strategies.
作者信息
Takayama Hiromitsu
机构信息
Graduate School of Pharmaceutical Sciences, Chiba University.
出版信息
Chem Pharm Bull (Tokyo). 2020;68(2):103-116. doi: 10.1248/cpb.c19-00872.
PMID:32009077
Abstract
The merits of biogenetic considerations in the chemical syntheses of natural products have been emphasized by describing the total syntheses of Lycopodium alkaloids; lycodine, flabellidine, lycopodine, and flabelliformine, as well as monoterpenoid indole alkaloids; C-mavacurine, kopsiyunnanine K, koumine, and 11-methoxy-19R-hydroxygelselegine.
摘要
通过描述石松生物碱（石松定、扇叶石松定、石松碱和扇叶石松碱）以及单萜吲哚生物碱（C-马瓦库林、云南柯蒲木碱K、钩吻素子和11-甲氧基-19R-羟基格氏千里光碱）的全合成，强调了生物遗传学考虑在天然产物化学合成中的优点。
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